Drug interactions
Levalbuterol + Perphenazine
Severity: Minor
Levalbuterol and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
No well-established interaction affects sedation. Both drugs may increase heart rate, and perphenazine can prolong QT while beta-agonists may lower potassium, so there is a small theoretical arrhythmia concern at high doses.
What this interaction means in plain words
Levalbuterol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive QT and cardiac effects; no established mechanism for the sedation effect.
What to do
No routine change is needed. Consider checking potassium and an ECG in patients with cardiac risk factors using high-dose levalbuterol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Levalbuterol with Perphenazine?
MediHelp rates the interaction as minor. Levalbuterol and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. No well-established interaction affects sedation. Both drugs may increase heart rate, and perphenazine can prolong QT while beta-agonists may lower potassium, so there is a small theoretical arrhythmia concern at high doses.
How serious is the interaction between Levalbuterol and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Consider checking potassium and an ECG in patients with cardiac risk factors using high-dose levalbuterol.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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