Drug interactions
Levetiracetam + Lorazepam
Severity: Minor
Levetiracetam and Lorazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and coordination problems, and these effects add together when they are combined. They are commonly co-prescribed for seizures, and the combination is generally manageable.
What this interaction means in plain words
Levetiracetam and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; levetiracetam has no relevant pharmacokinetic interaction with lorazepam.
What to do
Monitor for drowsiness and dizziness, particularly when starting or increasing doses. Advise caution when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lorazepam
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Lorazepam?
MediHelp rates the interaction as minor. Levetiracetam and Lorazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and coordination problems, and these effects add together when they are combined. They are commonly co-prescribed for seizures, and the combination is generally manageable.
How serious is the interaction between Levetiracetam and Lorazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and dizziness, particularly when starting or increasing doses. Advise caution when driving.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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