Drug interactions
Levetiracetam + Lumateperone
Severity: Moderate
Levetiracetam and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumateperone commonly causes somnolence and sedation, and levetiracetam also causes drowsiness. Combined use may increase sedation and impair psychomotor performance.
What this interaction means in plain words
Levetiracetam and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Lumateperone belongs to Central Nervous System.
Why it happens
Additive CNS depression from an atypical antipsychotic and an antiepileptic.
What to do
Monitor for excessive sedation and orthostasis, especially early in therapy. Advise caution with driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Lumateperone
Frequently asked questions
Can I take Levetiracetam with Lumateperone?
MediHelp rates the interaction as moderate. Levetiracetam and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumateperone commonly causes somnolence and sedation, and levetiracetam also causes drowsiness. Combined use may increase sedation and impair psychomotor performance.
How serious is the interaction between Levetiracetam and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and orthostasis, especially early in therapy. Advise caution with driving until response is known.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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