Drug interactions
Levetiracetam + Methadone
Severity: Moderate
Levetiracetam and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness, so together they can add to sedation and psychomotor impairment. Serious respiratory depression is much less likely than with other sedatives, but is possible.
What this interaction means in plain words
Levetiracetam and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess sedation, especially when starting or increasing either drug. Advise the patient about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Methadone?
MediHelp rates the interaction as moderate. Levetiracetam and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness and dizziness, so together they can add to sedation and psychomotor impairment. Serious respiratory depression is much less likely than with other sedatives, but is possible.
How serious is the interaction between Levetiracetam and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, especially when starting or increasing either drug. Advise the patient about driving and operating machinery.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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