Drug interactions
Levetiracetam + Morphine
Severity: Minor
Levetiracetam and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam may cause somnolence and dizziness, which can add to the sedation of morphine. No notable pharmacokinetic interaction is expected.
What this interaction means in plain words
Levetiracetam and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects without a significant pharmacokinetic interaction.
What to do
Counsel patients about drowsiness and monitor for excessive sedation when starting or increasing either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Morphine?
MediHelp rates the interaction as minor. Levetiracetam and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levetiracetam may cause somnolence and dizziness, which can add to the sedation of morphine. No notable pharmacokinetic interaction is expected.
How serious is the interaction between Levetiracetam and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and monitor for excessive sedation when starting or increasing either drug.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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