Drug interactions
Levetiracetam + Nortriptyline
Severity: Minor
Levetiracetam and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness and dizziness. Combined use may increase sedation and impair alertness. Nortriptyline may also lower the seizure threshold, opposing the antiseizure effect.
What this interaction means in plain words
Levetiracetam and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levetiracetam belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; tricyclics lower the seizure threshold.
What to do
Counsel patients about drowsiness and driving. Monitor seizure control after starting or adjusting nortriptyline.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Levetiracetam with Nortriptyline?
MediHelp rates the interaction as minor. Levetiracetam and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause drowsiness and dizziness. Combined use may increase sedation and impair alertness. Nortriptyline may also lower the seizure threshold, opposing the antiseizure effect.
How serious is the interaction between Levetiracetam and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving. Monitor seizure control after starting or adjusting nortriptyline.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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