Drug interactions
Levetiracetam + Suvorexant
Severity: Moderate
Levetiracetam and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant is an orexin antagonist hypnotic that can cause next-day somnolence and impaired driving. Levetiracetam may add to drowsiness and psychomotor impairment.
What this interaction means in plain words
Levetiracetam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levetiracetam belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Start suvorexant at the lowest dose and monitor for next-day sedation. Counsel patients about driving and other alertness-dependent tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Other interactions of Suvorexant
Frequently asked questions
Can I take Levetiracetam with Suvorexant?
MediHelp rates the interaction as moderate. Levetiracetam and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant is an orexin antagonist hypnotic that can cause next-day somnolence and impaired driving. Levetiracetam may add to drowsiness and psychomotor impairment.
How serious is the interaction between Levetiracetam and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start suvorexant at the lowest dose and monitor for next-day sedation. Counsel patients about driving and other alertness-dependent tasks.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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