Drug interactions
Levocetirizine + Phenelzine
Severity: Moderate
Levocetirizine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine can potentiate the sedative effects of antihistamines, and its MAO inhibition may intensify anticholinergic effects. Levocetirizine has weak anticholinergic activity, so the effect is likely modest, but drowsiness may increase.
What this interaction means in plain words
Levocetirizine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levocetirizine belongs to Respiratory; Phenelzine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible potentiation of anticholinergic effects by MAO inhibition.
What to do
Monitor for excessive sedation, dizziness and anticholinergic effects when combining. Use the lowest levocetirizine dose and advise against driving until response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Levocetirizine with Phenelzine?
MediHelp rates the interaction as moderate. Levocetirizine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenelzine can potentiate the sedative effects of antihistamines, and its MAO inhibition may intensify anticholinergic effects. Levocetirizine has weak anticholinergic activity, so the effect is likely modest, but drowsiness may increase.
How serious is the interaction between Levocetirizine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, dizziness and anticholinergic effects when combining. Use the lowest levocetirizine dose and advise against driving until response is known.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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