Drug interactions
Levocetirizine + Zuranolone
Severity: Moderate
Levocetirizine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes marked somnolence and driving impairment, and levocetirizine may add to this effect. The combination can increase CNS depression and reduce psychomotor performance.
What this interaction means in plain words
Levocetirizine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levocetirizine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from a GABA-A positive modulator and a sedating antihistamine.
What to do
Counsel the patient on additive sedation and avoiding driving. Consider a lower zuranolone dose if excess sedation occurs, or stop levocetirizine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levocetirizine
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Levocetirizine with Zuranolone?
MediHelp rates the interaction as moderate. Levocetirizine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes marked somnolence and driving impairment, and levocetirizine may add to this effect. The combination can increase CNS depression and reduce psychomotor performance.
How serious is the interaction between Levocetirizine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on additive sedation and avoiding driving. Consider a lower zuranolone dose if excess sedation occurs, or stop levocetirizine.
What other medicines interact with Levocetirizine?
MediHelp also lists interactions of Levocetirizine with, for example, Acrivastine, Asenapine transdermal, Avapritinib. The full list is on the Levocetirizine page.
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