Drug interactions
Levodopa + Lisinopril
Severity: Moderate
Levodopa and Lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, especially early in treatment. Combined with lisinopril, blood pressure falls may be more pronounced, increasing the risk of dizziness and falls.
What this interaction means in plain words
Levodopa and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Lisinopril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of dopaminergic vasodilation and ACE inhibition.
What to do
Check sitting and standing blood pressure when levodopa is started or adjusted. Reduce the antihypertensive dose if orthostatic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Lisinopril?
MediHelp rates the interaction as moderate. Levodopa and Lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, especially early in treatment. Combined with lisinopril, blood pressure falls may be more pronounced, increasing the risk of dizziness and falls.
How serious is the interaction between Levodopa and Lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check sitting and standing blood pressure when levodopa is started or adjusted. Reduce the antihypertensive dose if orthostatic symptoms develop.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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