Drug interactions
Levodopa + Oxybutynin
Severity: Minor
Levodopa and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics may add to the benefit of levodopa on tremor, but they can worsen dyskinesia and cause confusion. Large anticholinergic doses may slow gastric emptying and delay levodopa absorption, reducing its effect.
What this interaction means in plain words
Levodopa and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levodopa belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Pharmacodynamic interaction with opposing cholinergic and dopaminergic activity, plus delayed gastric emptying that slows levodopa absorption.
What to do
Monitor motor response, dyskinesia and cognition, and adjust levodopa timing or reduce the oxybutynin dose if fluctuations or confusion occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Oxybutynin?
MediHelp rates the interaction as minor. Levodopa and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anticholinergics may add to the benefit of levodopa on tremor, but they can worsen dyskinesia and cause confusion. Large anticholinergic doses may slow gastric emptying and delay levodopa absorption, reducing its effect.
How serious is the interaction between Levodopa and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response, dyskinesia and cognition, and adjust levodopa timing or reduce the oxybutynin dose if fluctuations or confusion occur.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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