Drug interactions
Levodopa + Ramipril
Severity: Moderate
Levodopa and Ramipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can lower blood pressure and cause orthostatic hypotension, and this adds to the effect of ramipril. The risk is greatest when levodopa is started or the dose is raised.
What this interaction means in plain words
Levodopa and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Ramipril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects through pharmacodynamic synergism.
What to do
Monitor sitting and standing blood pressure when levodopa is started or adjusted, and reduce the ramipril dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Ramipril?
MediHelp rates the interaction as moderate. Levodopa and Ramipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can lower blood pressure and cause orthostatic hypotension, and this adds to the effect of ramipril. The risk is greatest when levodopa is started or the dose is raised.
How serious is the interaction between Levodopa and Ramipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure when levodopa is started or adjusted, and reduce the ramipril dose if symptomatic hypotension occurs.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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