Drug interactions
Levodopa + Ropinirole
Severity: Moderate
Levodopa and Ropinirole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two drugs are commonly combined in Parkinson disease and have additive dopaminergic effects. Together they can increase dyskinesia, hallucinations, nausea, orthostatic hypotension and somnolence. Ropinirole has also been reported to modestly raise levodopa levels.
What this interaction means in plain words
Levodopa and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Ropinirole belongs to Central Nervous System.
Why it happens
Additive dopaminergic stimulation through levodopa conversion to dopamine and direct D2/D3 agonism by ropinirole.
What to do
Titrate both drugs slowly and reduce the levodopa dose if dyskinesia or psychiatric effects emerge. Monitor blood pressure and daytime sleepiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levodopa and Ropinirole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ropinirole
- Amisulpride + Ropinirole Contraindicated
- Chlorpromazine + Ropinirole Major
- Droperidol + Ropinirole Major
- Fluphenazine + Ropinirole Major
- Fluvoxamine + Ropinirole Major
- Haloperidol + Ropinirole Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Ropinirole?
MediHelp rates the interaction as moderate. Levodopa and Ropinirole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The two drugs are commonly combined in Parkinson disease and have additive dopaminergic effects. Together they can increase dyskinesia, hallucinations, nausea, orthostatic hypotension and somnolence. Ropinirole has also been reported to modestly raise levodopa levels.
How serious is the interaction between Levodopa and Ropinirole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both drugs slowly and reduce the levodopa dose if dyskinesia or psychiatric effects emerge. Monitor blood pressure and daytime sleepiness.
What other medicines interact with Ropinirole?
MediHelp also lists interactions of Ropinirole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Ropinirole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
