Drug interactions
Levodopa + Tolterodine
Severity: Minor
Levodopa and Tolterodine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antimuscarinics like tolterodine have pharmacodynamic overlap with levodopa therapy in parkinsonism. They may slow gastric emptying and reduce levodopa absorption, and can worsen dyskinesia or cause confusion and constipation. Tolterodine has limited CNS penetration, so the effect is usually minor.
What this interaction means in plain words
Levodopa and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levodopa belongs to Central Nervous System; Tolterodine belongs to Genitourinary.
Why it happens
Anticholinergic delay of gastric emptying may reduce levodopa absorption, with additive central cholinergic-dopaminergic effects.
What to do
Monitor motor response and for confusion or constipation, and adjust levodopa if parkinsonian control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolterodine
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Tolterodine?
MediHelp rates the interaction as minor. Levodopa and Tolterodine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antimuscarinics like tolterodine have pharmacodynamic overlap with levodopa therapy in parkinsonism. They may slow gastric emptying and reduce levodopa absorption, and can worsen dyskinesia or cause confusion and constipation. Tolterodine has limited CNS penetration, so the effect is usually minor.
How serious is the interaction between Levodopa and Tolterodine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor response and for confusion or constipation, and adjust levodopa if parkinsonian control worsens.
What other medicines interact with Tolterodine?
MediHelp also lists interactions of Tolterodine with, for example, Clarithromycin, Clozapine, Cobicistat. The full list is on the Tolterodine page.
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