Drug interactions
Levodopa + Valsartan
Severity: Moderate
Levodopa and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and combining it with an antihypertensive such as valsartan can add to blood pressure lowering. Patients may experience dizziness or falls, especially at initiation or after dose increases.
What this interaction means in plain words
Levodopa and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levodopa belongs to Central Nervous System; Valsartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of dopaminergic stimulation and angiotensin receptor blockade.
What to do
Monitor blood pressure including standing measurements when starting or increasing levodopa. Lower the valsartan dose if symptomatic orthostatic hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Levodopa with Valsartan?
MediHelp rates the interaction as moderate. Levodopa and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and combining it with an antihypertensive such as valsartan can add to blood pressure lowering. Patients may experience dizziness or falls, especially at initiation or after dose increases.
How serious is the interaction between Levodopa and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing measurements when starting or increasing levodopa. Lower the valsartan dose if symptomatic orthostatic hypotension develops.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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