Drug interactions
Levofloxacin + Meloxicam
Severity: Moderate
Levofloxacin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can lower the seizure threshold, and NSAIDs may increase the likelihood of CNS stimulation or convulsions. The concern is greatest in patients with epilepsy, CNS lesions or renal impairment.
What this interaction means in plain words
Levofloxacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Meloxicam belongs to Musculoskeletal.
Why it happens
Fluoroquinolone inhibition of GABA binding at GABA-A receptors, which NSAIDs may potentiate.
What to do
Avoid the combination in patients with seizure risk factors and adjust levofloxacin dose for renal function. Discontinue the fluoroquinolone if CNS excitation or seizures occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Meloxicam?
MediHelp rates the interaction as moderate. Levofloxacin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can lower the seizure threshold, and NSAIDs may increase the likelihood of CNS stimulation or convulsions. The concern is greatest in patients with epilepsy, CNS lesions or renal impairment.
How serious is the interaction between Levofloxacin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure risk factors and adjust levofloxacin dose for renal function. Discontinue the fluoroquinolone if CNS excitation or seizures occur.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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