Drug interactions
Levofloxacin + Metformin-repaglinide
Severity: Moderate
Levofloxacin and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia is a particular concern with insulin secretagogues like repaglinide.
What this interaction means in plain words
Levofloxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Metformin-repaglinide belongs to Endocrine.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release through effects on potassium channels, causing dysglycemia.
What to do
Monitor blood glucose closely during levofloxacin therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and choose an alternative if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levofloxacin and Metformin-repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Levofloxacin and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones such as levofloxacin can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs. Severe hypoglycemia is a particular concern with insulin secretagogues like repaglinide.
How serious is the interaction between Levofloxacin and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during levofloxacin therapy and counsel the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and choose an alternative if significant dysglycemia occurs.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
