Drug interactions
Levofloxacin + Naproxen
Severity: Moderate
Levofloxacin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a fluoroquinolone may increase the chance of CNS excitation and convulsions. The absolute risk is low but matters in patients predisposed to seizures.
What this interaction means in plain words
Levofloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Naproxen belongs to Musculoskeletal.
Why it happens
Fluoroquinolones inhibit GABA binding at GABA-A receptors, and NSAIDs may enhance this effect.
What to do
Avoid in patients with epilepsy or a lowered seizure threshold, and use an alternative antibiotic if needed. Dose levofloxacin according to renal function and monitor for neurological symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Naproxen?
MediHelp rates the interaction as moderate. Levofloxacin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a fluoroquinolone may increase the chance of CNS excitation and convulsions. The absolute risk is low but matters in patients predisposed to seizures.
How serious is the interaction between Levofloxacin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or a lowered seizure threshold, and use an alternative antibiotic if needed. Dose levofloxacin according to renal function and monitor for neurological symptoms.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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