Drug interactions
Levofloxacin + Paroxetine
Severity: Minor
Levofloxacin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin prolongs the QT interval, and paroxetine has a small potential for QT effects, mainly in overdose or at high exposure. Combined use may modestly increase arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Levofloxacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levofloxacin belongs to Anti Bacterial; Paroxetine belongs to Central Nervous System.
Why it happens
Possible additive effect on ventricular repolarization; paroxetine's contribution is weak.
What to do
No routine action is needed for most patients; check ECG and electrolytes in patients with other QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Levofloxacin with Paroxetine?
MediHelp rates the interaction as minor. Levofloxacin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levofloxacin prolongs the QT interval, and paroxetine has a small potential for QT effects, mainly in overdose or at high exposure. Combined use may modestly increase arrhythmia risk in vulnerable patients.
How serious is the interaction between Levofloxacin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed for most patients; check ECG and electrolytes in patients with other QT risk factors.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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