Drug interactions
Levofloxacin + Sunitinib
Severity: Moderate
Levofloxacin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin and sunitinib can each prolong the QT interval, and used together they may increase the chance of serious ventricular arrhythmia including torsades de pointes. Patients with cardiac disease or electrolyte abnormalities are at higher risk.
What this interaction means in plain words
Levofloxacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Sunitinib belongs to Oncology.
Why it happens
Additive inhibition of cardiac repolarization causing QT prolongation.
What to do
Check a baseline ECG and electrolytes, correct hypokalemia or hypomagnesemia, and repeat ECG during co-treatment. Prefer an antibiotic without QT effect if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Levofloxacin with Sunitinib?
MediHelp rates the interaction as moderate. Levofloxacin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin and sunitinib can each prolong the QT interval, and used together they may increase the chance of serious ventricular arrhythmia including torsades de pointes. Patients with cardiac disease or electrolyte abnormalities are at higher risk.
How serious is the interaction between Levofloxacin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correct hypokalemia or hypomagnesemia, and repeat ECG during co-treatment. Prefer an antibiotic without QT effect if feasible.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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