Drug interactions
Levofloxacin + Telavancin
Severity: Moderate
Levofloxacin and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levofloxacin can prolong the QT interval and telavancin may have an additive effect. This raises the risk of torsades de pointes, particularly with hypokalemia, bradycardia or heart disease.
What this interaction means in plain words
Levofloxacin and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levofloxacin belongs to Anti Bacterial; Telavancin belongs to Anti Bacterial.
Why it happens
Additive QTc prolongation; fluoroquinolones block cardiac hERG potassium channels.
What to do
Obtain a baseline ECG and correct electrolytes. Monitor the QTc, or choose a non-QT-prolonging antibacterial where appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Levofloxacin with Telavancin?
MediHelp rates the interaction as moderate. Levofloxacin and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levofloxacin can prolong the QT interval and telavancin may have an additive effect. This raises the risk of torsades de pointes, particularly with hypokalemia, bradycardia or heart disease.
How serious is the interaction between Levofloxacin and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Monitor the QTc, or choose a non-QT-prolonging antibacterial where appropriate.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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