Drug interactions
Levomilnacipran + Olanzapine
Severity: Moderate
Levomilnacipran and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with an antipsychotic may increase the risk of serotonin syndrome and, rarely, neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate.
What this interaction means in plain words
Levomilnacipran and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levomilnacipran belongs to Central Nervous System; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic interaction: increased serotonergic activity with dopamine D2 blockade.
What to do
Monitor for signs of serotonin toxicity (agitation, tremor, hyperreflexia, hyperthermia) and neuroleptic malignant syndrome. Stop one or both agents if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Levomilnacipran with Olanzapine?
MediHelp rates the interaction as moderate. Levomilnacipran and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran is a serotonin-norepinephrine reuptake inhibitor, and combining it with an antipsychotic may increase the risk of serotonin syndrome and, rarely, neuroleptic malignant syndrome. Levomilnacipran can also raise blood pressure and heart rate.
How serious is the interaction between Levomilnacipran and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity (agitation, tremor, hyperreflexia, hyperthermia) and neuroleptic malignant syndrome. Stop one or both agents if these occur.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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