Drug interactions
Levonorgestrel + Mifepristone
Severity: Moderate
Levonorgestrel and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a progesterone receptor antagonist and CYP3A4 inhibitor, so it may blunt the progestogenic effect of levonorgestrel while raising its levels. Contraceptive efficacy may be reduced and hormonal effects may be unpredictable.
What this interaction means in plain words
Levonorgestrel and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism at the progesterone receptor plus CYP3A4 inhibition by mifepristone.
What to do
Do not rely on levonorgestrel for contraception or endometrial protection while on mifepristone. Delay starting hormonal contraception per product guidance or use a non-hormonal method.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Mifepristone?
MediHelp rates the interaction as moderate. Levonorgestrel and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is a progesterone receptor antagonist and CYP3A4 inhibitor, so it may blunt the progestogenic effect of levonorgestrel while raising its levels. Contraceptive efficacy may be reduced and hormonal effects may be unpredictable.
How serious is the interaction between Levonorgestrel and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on levonorgestrel for contraception or endometrial protection while on mifepristone. Delay starting hormonal contraception per product guidance or use a non-hormonal method.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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