Drug interactions
Levonorgestrel + Pexidartinib
Severity: Moderate
Levonorgestrel and Pexidartinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a risk of serious hepatotoxicity, and hormonal agents can rarely contribute to liver injury. The combined hepatic risk is mostly theoretical for low-dose levonorgestrel.
What this interaction means in plain words
Levonorgestrel and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levonorgestrel belongs to Endocrine; Pexidartinib belongs to Oncology.
Why it happens
Potential additive hepatotoxicity; no specific pharmacokinetic mechanism is established.
What to do
Monitor liver enzymes per pexidartinib labeling and stop therapy if hepatotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levonorgestrel
Other interactions of Pexidartinib
Frequently asked questions
Can I take Levonorgestrel with Pexidartinib?
MediHelp rates the interaction as moderate. Levonorgestrel and Pexidartinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a risk of serious hepatotoxicity, and hormonal agents can rarely contribute to liver injury. The combined hepatic risk is mostly theoretical for low-dose levonorgestrel.
How serious is the interaction between Levonorgestrel and Pexidartinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes per pexidartinib labeling and stop therapy if hepatotoxicity develops.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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