Drug interactions
Levonorgestrel + Saxagliptin-metformin
Severity: Minor
Levonorgestrel and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins such as levonorgestrel can modestly impair glucose tolerance and insulin sensitivity in some patients. This may slightly weaken glycemic control in people taking saxagliptin-metformin, though the effect is generally small with low-dose contraceptive regimens.
What this interaction means in plain words
Levonorgestrel and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism, as progestins may reduce insulin sensitivity and raise glucose.
What to do
No routine change is needed; check fasting glucose or HbA1c after starting or stopping the progestin and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levonorgestrel and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Levonorgestrel with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Levonorgestrel and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins such as levonorgestrel can modestly impair glucose tolerance and insulin sensitivity in some patients. This may slightly weaken glycemic control in people taking saxagliptin-metformin, though the effect is generally small with low-dose contraceptive regimens.
How serious is the interaction between Levonorgestrel and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check fasting glucose or HbA1c after starting or stopping the progestin and adjust antidiabetic therapy if control worsens.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
