Drug interactions
Levonorgestrel + Voxelotor
Severity: Minor
Levonorgestrel and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor can inhibit CYP3A4 and may raise levonorgestrel concentrations modestly. Clinical relevance is low because levonorgestrel has a wide therapeutic margin.
What this interaction means in plain words
Levonorgestrel and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Levonorgestrel belongs to Endocrine; Voxelotor belongs to Miscellaneous.
Why it happens
CYP3A4 inhibition reduces levonorgestrel metabolism.
What to do
No dose adjustment is generally needed; monitor for progestogenic adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levonorgestrel
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Levonorgestrel with Voxelotor?
MediHelp rates the interaction as minor. Levonorgestrel and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor can inhibit CYP3A4 and may raise levonorgestrel concentrations modestly. Clinical relevance is low because levonorgestrel has a wide therapeutic margin.
How serious is the interaction between Levonorgestrel and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for progestogenic adverse effects.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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