Drug interactions
Levonorgestrel intrauterine + Ribociclib
Severity: Minor
Levonorgestrel intrauterine and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine system acts mainly locally with low systemic levonorgestrel exposure, so any rise in systemic levels from CYP3A4 inhibition is unlikely to be clinically important.
What this interaction means in plain words
Levonorgestrel intrauterine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical CYP3A4 inhibition by ribociclib raising low systemic levonorgestrel levels.
What to do
No action is needed; counsel the patient on usual progestogen adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Levonorgestrel intrauterine with Ribociclib?
MediHelp rates the interaction as minor. Levonorgestrel intrauterine and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine system acts mainly locally with low systemic levonorgestrel exposure, so any rise in systemic levels from CYP3A4 inhibition is unlikely to be clinically important.
How serious is the interaction between Levonorgestrel intrauterine and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed; counsel the patient on usual progestogen adverse effects.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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