Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Midazolam
Severity: Minor
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Midazolam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The ethinylestradiol in this contraceptive may slightly reduce midazolam clearance and increase exposure. The effect is typically small and may mildly prolong sedation.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak inhibition of CYP3A4 metabolism of midazolam by ethinylestradiol.
What to do
No dose change is usually needed; titrate midazolam to effect and observe for prolonged sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Midazolam?
MediHelp rates the interaction as minor. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Midazolam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The ethinylestradiol in this contraceptive may slightly reduce midazolam clearance and increase exposure. The effect is typically small and may mildly prolong sedation.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Midazolam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; titrate midazolam to effect and observe for prolonged sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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