Drug interactions
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate + Voriconazole
Severity: Moderate
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases ethinylestradiol and progestin exposure, and the oral contraceptive may raise voriconazole levels. This may increase hormonal adverse effects and voriconazole-related adverse effects.
What this interaction means in plain words
Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of the contraceptive steroids, and ethinylestradiol may inhibit voriconazole metabolism.
What to do
Monitor for estrogenic effects and voriconazole toxicity such as visual disturbances and hepatotoxicity; adjust doses if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate with Voriconazole?
MediHelp rates the interaction as moderate. Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole increases ethinylestradiol and progestin exposure, and the oral contraceptive may raise voriconazole levels. This may increase hormonal adverse effects and voriconazole-related adverse effects.
How serious is the interaction between Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic effects and voriconazole toxicity such as visual disturbances and hepatotoxicity; adjust doses if adverse effects occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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