Drug interactions
Levorphanol + Paliperidone
Severity: Moderate
Levorphanol and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can deepen sedation and slow psychomotor function. Opioids may also add to the orthostatic hypotension seen with paliperidone, and respiratory depression is possible at higher opioid doses.
What this interaction means in plain words
Levorphanol and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid receptor agonism and antipsychotic antihistaminic/alpha-blocking activity.
What to do
Start with the lowest effective opioid dose and monitor for excessive sedation, hypotension and slowed breathing. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levorphanol and Paliperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Levorphanol with Paliperidone?
MediHelp rates the interaction as moderate. Levorphanol and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can deepen sedation and slow psychomotor function. Opioids may also add to the orthostatic hypotension seen with paliperidone, and respiratory depression is possible at higher opioid doses.
How serious is the interaction between Levorphanol and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective opioid dose and monitor for excessive sedation, hypotension and slowed breathing. Advise patients to avoid driving and alcohol.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
