Drug interactions
Levosalbutamol + Metoprolol
Severity: Moderate
Levosalbutamol and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoprolol is a beta-1 selective blocker, but it can still blunt the bronchodilator effect of levosalbutamol and, at higher doses, cause bronchospasm in patients with airway disease. The effect is less than with nonselective agents.
What this interaction means in plain words
Levosalbutamol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Metoprolol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta adrenoceptors, with loss of cardioselectivity at higher metoprolol doses.
What to do
Use the lowest effective metoprolol dose in patients with asthma or COPD and monitor respiratory symptoms and bronchodilator response. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Levosalbutamol and Metoprolol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levosalbutamol
Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Levosalbutamol with Metoprolol?
MediHelp rates the interaction as moderate. Levosalbutamol and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoprolol is a beta-1 selective blocker, but it can still blunt the bronchodilator effect of levosalbutamol and, at higher doses, cause bronchospasm in patients with airway disease. The effect is less than with nonselective agents.
How serious is the interaction between Levosalbutamol and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective metoprolol dose in patients with asthma or COPD and monitor respiratory symptoms and bronchodilator response. Consider a non-beta-blocker alternative in patients with significant reactive airway disease.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
