Drug interactions
Levosalbutamol + Osilodrostat
Severity: Moderate
Levosalbutamol and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and it may also cause hypokalemia through cortisol-pathway effects. Levosalbutamol can add to QT risk and lower potassium, so the combination may increase arrhythmia risk in susceptible patients.
What this interaction means in plain words
Levosalbutamol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levosalbutamol belongs to Respiratory; Osilodrostat belongs to Endocrine.
Why it happens
Additive QTc prolongation, with potassium lowering from both drugs.
What to do
Check potassium and magnesium and correct deficits before starting and during combined use. Obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Osilodrostat
Frequently asked questions
Can I take Levosalbutamol with Osilodrostat?
MediHelp rates the interaction as moderate. Levosalbutamol and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and it may also cause hypokalemia through cortisol-pathway effects. Levosalbutamol can add to QT risk and lower potassium, so the combination may increase arrhythmia risk in susceptible patients.
How serious is the interaction between Levosalbutamol and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and correct deficits before starting and during combined use. Obtain an ECG in patients with other QT risk factors.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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