Drug interactions
Levothyroxine + Nateglinide
Severity: Moderate
Levothyroxine and Nateglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levothyroxine can raise blood glucose and so may reduce the effect of nateglinide, particularly when thyroid dose is increased. Glycemic control may shift when thyroid replacement is started or adjusted.
What this interaction means in plain words
Levothyroxine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Nateglinide belongs to Endocrine.
Why it happens
Thyroid hormone increases glucose production and metabolism, pharmacodynamically opposing the hypoglycemic effect of nateglinide.
What to do
Monitor blood glucose more closely when levothyroxine is started or its dose is changed. Adjust the nateglinide dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Levothyroxine with Nateglinide?
MediHelp rates the interaction as moderate. Levothyroxine and Nateglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levothyroxine can raise blood glucose and so may reduce the effect of nateglinide, particularly when thyroid dose is increased. Glycemic control may shift when thyroid replacement is started or adjusted.
How serious is the interaction between Levothyroxine and Nateglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when levothyroxine is started or its dose is changed. Adjust the nateglinide dose if control worsens.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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