Drug interactions
Levothyroxine + Oxcarbazepine
Severity: Moderate
Levothyroxine and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce thyroid hormone levels and has been associated with lower T4 in some patients. Patients on replacement therapy may develop hypothyroid features.
What this interaction means in plain words
Levothyroxine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine likely induces hepatic metabolism and glucuronidation of thyroid hormones.
What to do
Monitor TSH and free T4 after starting or stopping oxcarbazepine and adjust the levothyroxine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Levothyroxine
Frequently asked questions
Can I take Levothyroxine with Oxcarbazepine?
MediHelp rates the interaction as moderate. Levothyroxine and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce thyroid hormone levels and has been associated with lower T4 in some patients. Patients on replacement therapy may develop hypothyroid features.
How serious is the interaction between Levothyroxine and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor TSH and free T4 after starting or stopping oxcarbazepine and adjust the levothyroxine dose accordingly.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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