Drug interactions
Levothyroxine + Patiromer
Severity: Moderate
Levothyroxine and Patiromer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patiromer is a non-absorbed polymer that can bind co-administered oral drugs in the gut, reducing levothyroxine absorption. This may lead to under-replacement of thyroid hormone.
What this interaction means in plain words
Levothyroxine and Patiromer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Patiromer belongs to Miscellaneous.
Why it happens
Patiromer binds levothyroxine in the gastrointestinal tract, reducing its absorption.
What to do
Give levothyroxine at least 3 hours before or after patiromer. Monitor TSH when therapy is started or changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Other interactions of Patiromer
- Alogliptin-metformin + Patiromer Moderate
- Canagliflozin-metformin + Patiromer Moderate
- Carvedilol + Patiromer Moderate
- Ciprofloxacin + Patiromer Moderate
- Dapagliflozin-metformin + Patiromer Moderate
- Empagliflozin-metformin + Patiromer Moderate
Frequently asked questions
Can I take Levothyroxine with Patiromer?
MediHelp rates the interaction as moderate. Levothyroxine and Patiromer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patiromer is a non-absorbed polymer that can bind co-administered oral drugs in the gut, reducing levothyroxine absorption. This may lead to under-replacement of thyroid hormone.
How serious is the interaction between Levothyroxine and Patiromer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give levothyroxine at least 3 hours before or after patiromer. Monitor TSH when therapy is started or changed.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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