Drug interactions
Levothyroxine + Sucroferric oxyhydroxide
Severity: Moderate
Levothyroxine and Sucroferric oxyhydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron-based phosphate binders can bind oral levothyroxine in the gut and reduce its absorption, potentially raising TSH. Parenteral levothyroxine is not affected.
What this interaction means in plain words
Levothyroxine and Sucroferric oxyhydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Levothyroxine belongs to Endocrine; Sucroferric oxyhydroxide belongs to Genitourinary.
Why it happens
Iron binds or chelates levothyroxine in the gastrointestinal tract, reducing absorption.
What to do
Give oral levothyroxine at least 4 hours before sucroferric oxyhydroxide. Monitor TSH after starting or changing the binder.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levothyroxine
Other interactions of Sucroferric oxyhydroxide
Frequently asked questions
Can I take Levothyroxine with Sucroferric oxyhydroxide?
MediHelp rates the interaction as moderate. Levothyroxine and Sucroferric oxyhydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iron-based phosphate binders can bind oral levothyroxine in the gut and reduce its absorption, potentially raising TSH. Parenteral levothyroxine is not affected.
How serious is the interaction between Levothyroxine and Sucroferric oxyhydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral levothyroxine at least 4 hours before sucroferric oxyhydroxide. Monitor TSH after starting or changing the binder.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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