Drug interactions
Lidocaine + Naloxegol
Severity: Minor
Lidocaine and Naloxegol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naloxegol is a CYP3A4 and P-gp substrate and its exposure rises with moderate or strong CYP3A4 inhibitors. Lidocaine is only a weak inhibitor, so any effect is expected to be small.
What this interaction means in plain words
Lidocaine and Naloxegol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Naloxegol belongs to Gastrointestinal Tract.
Why it happens
Weak CYP3A4 inhibition by lidocaine may slightly raise naloxegol levels.
What to do
No dose adjustment is needed; watch for abdominal pain, diarrhea or opioid withdrawal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Naloxegol
- Clarithromycin + Naloxegol Contraindicated
- Itraconazole + Naloxegol Contraindicated
- Ketoconazole + Naloxegol Contraindicated
- Naloxegol + Posaconazole Contraindicated
- Naloxegol + Voriconazole Contraindicated
- Bupropion-naltrexone + Naloxegol Major
Frequently asked questions
Can I take Lidocaine with Naloxegol?
MediHelp rates the interaction as minor. Lidocaine and Naloxegol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naloxegol is a CYP3A4 and P-gp substrate and its exposure rises with moderate or strong CYP3A4 inhibitors. Lidocaine is only a weak inhibitor, so any effect is expected to be small.
How serious is the interaction between Lidocaine and Naloxegol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; watch for abdominal pain, diarrhea or opioid withdrawal symptoms.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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