Drug interactions
Lidocaine + Oxymorphone
Severity: Minor
Lidocaine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine can produce drowsiness and CNS depression at higher exposures, which may add to opioid sedation. The effect is generally modest at usual therapeutic doses, but opioids can add to central effects.
What this interaction means in plain words
Lidocaine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine belongs to Cardiovascular; Oxymorphone belongs to Musculoskeletal.
Why it happens
Possible additive CNS depression; lidocaine has central effects at systemic concentrations.
What to do
No routine change is needed; watch for excess sedation when lidocaine is given systemically or in large doses alongside oxymorphone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Frequently asked questions
Can I take Lidocaine with Oxymorphone?
MediHelp rates the interaction as minor. Lidocaine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic lidocaine can produce drowsiness and CNS depression at higher exposures, which may add to opioid sedation. The effect is generally modest at usual therapeutic doses, but opioids can add to central effects.
How serious is the interaction between Lidocaine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for excess sedation when lidocaine is given systemically or in large doses alongside oxymorphone.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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