Drug interactions
Lidocaine + Secobarbital
Severity: Moderate
Lidocaine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may increase lidocaine metabolism, lowering its plasma levels and possibly reducing antiarrhythmic effect. Additive CNS depression is also possible with systemic lidocaine.
What this interaction means in plain words
Lidocaine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate-mediated induction of hepatic CYP enzymes (including CYP3A4 and CYP1A2) increases lidocaine clearance; additive CNS depression.
What to do
Monitor lidocaine response and plasma levels when used systemically and adjust the dose as needed; watch for excess sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Lidocaine with Secobarbital?
MediHelp rates the interaction as moderate. Lidocaine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may increase lidocaine metabolism, lowering its plasma levels and possibly reducing antiarrhythmic effect. Additive CNS depression is also possible with systemic lidocaine.
How serious is the interaction between Lidocaine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lidocaine response and plasma levels when used systemically and adjust the dose as needed; watch for excess sedation.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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