Drug interactions
Lidocaine + Sufentanil
Severity: Moderate
Lidocaine and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic lidocaine can add to the sedative and respiratory depressant effects of sufentanil, a very potent opioid. Sufentanil is also a CYP3A4 substrate, so a small rise in exposure is conceivable. The combination is common in anesthesia and needs monitoring.
What this interaction means in plain words
Lidocaine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lidocaine belongs to Cardiovascular; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression; weak CYP3A4 inhibition by lidocaine may slightly raise sufentanil levels.
What to do
Monitor sedation, oxygen saturation and respiratory rate, and reduce the opioid dose when giving systemic lidocaine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Lidocaine with Sufentanil?
MediHelp rates the interaction as moderate. Lidocaine and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic lidocaine can add to the sedative and respiratory depressant effects of sufentanil, a very potent opioid. Sufentanil is also a CYP3A4 substrate, so a small rise in exposure is conceivable. The combination is common in anesthesia and needs monitoring.
How serious is the interaction between Lidocaine and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, oxygen saturation and respiratory rate, and reduce the opioid dose when giving systemic lidocaine.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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