Drug interactions
Lidocaine-prilocaine + Suvorexant
Severity: Minor
Lidocaine-prilocaine and Suvorexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lidocaine is a weak CYP3A4 inhibitor and could modestly increase suvorexant exposure and daytime somnolence. With topical lidocaine-prilocaine the systemic exposure is low, so the effect is likely minimal.
What this interaction means in plain words
Lidocaine-prilocaine and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Lidocaine-prilocaine belongs to Genitourinary; Suvorexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by lidocaine may slightly reduce suvorexant clearance.
What to do
No dose change is needed for routine topical use. Counsel patients about next-day drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Lidocaine-prilocaine and Suvorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Suvorexant
Frequently asked questions
Can I take Lidocaine-prilocaine with Suvorexant?
MediHelp rates the interaction as minor. Lidocaine-prilocaine and Suvorexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lidocaine is a weak CYP3A4 inhibitor and could modestly increase suvorexant exposure and daytime somnolence. With topical lidocaine-prilocaine the systemic exposure is low, so the effect is likely minimal.
How serious is the interaction between Lidocaine-prilocaine and Suvorexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed for routine topical use. Counsel patients about next-day drowsiness.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
