Drug interactions
Linagliptin-metformin + Lorlatinib
Severity: Moderate
Linagliptin-metformin and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer and may lower linagliptin exposure. This could reduce glycemic control, although linagliptin is eliminated mostly unchanged and the effect is modest.
What this interaction means in plain words
Linagliptin-metformin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Lorlatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 (and possibly P-gp) increases linagliptin clearance.
What to do
Monitor blood glucose and HbA1c after starting lorlatinib. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Lorlatinib?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A4 inducer and may lower linagliptin exposure. This could reduce glycemic control, although linagliptin is eliminated mostly unchanged and the effect is modest.
How serious is the interaction between Linagliptin-metformin and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting lorlatinib. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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