Drug interactions
Linagliptin-metformin + Moexipril
Severity: Moderate
Linagliptin-metformin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and have been linked to occasional hypoglycemia in people taking antidiabetic drugs. They can also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis. Both effects are uncommon.
What this interaction means in plain words
Linagliptin-metformin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
ACE inhibition may improve insulin sensitivity, and hemodynamic effects on the kidney can reduce metformin clearance.
What to do
Monitor blood glucose and renal function, especially after initiation or dose changes, and review metformin dosing if eGFR falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Linagliptin-metformin with Moexipril?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and have been linked to occasional hypoglycemia in people taking antidiabetic drugs. They can also reduce renal function in susceptible patients, which could raise metformin exposure and the risk of lactic acidosis. Both effects are uncommon.
How serious is the interaction between Linagliptin-metformin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, especially after initiation or dose changes, and review metformin dosing if eGFR falls.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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