Drug interactions
Linagliptin-metformin + Nilotinib
Severity: Moderate
Linagliptin-metformin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib can cause hyperglycemia and glucose intolerance during treatment, which may reduce the effectiveness of antidiabetic therapy. Patients with diabetes may need closer glucose surveillance.
What this interaction means in plain words
Linagliptin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib-related hyperglycemia opposes the glucose-lowering effect through a mechanism that is not fully established.
What to do
Check glucose before starting nilotinib and monitor regularly during therapy; escalate antidiabetic treatment as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Nilotinib?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib can cause hyperglycemia and glucose intolerance during treatment, which may reduce the effectiveness of antidiabetic therapy. Patients with diabetes may need closer glucose surveillance.
How serious is the interaction between Linagliptin-metformin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting nilotinib and monitor regularly during therapy; escalate antidiabetic treatment as needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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