Drug interactions
Linagliptin-metformin + Ofloxacin
Severity: Moderate
Linagliptin-metformin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones including ofloxacin can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic drugs. Risk is greater in older adults and those with renal impairment. The risk is lower with metformin and linagliptin than with insulin or sulfonylureas.
What this interaction means in plain words
Linagliptin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, producing variable effects on glucose.
What to do
Monitor blood glucose during the course and advise patients on symptoms of dysglycemia; switch antibiotic if glucose disturbances occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Linagliptin-metformin with Ofloxacin?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones including ofloxacin can cause both hypoglycemia and hyperglycemia in patients receiving antidiabetic drugs. Risk is greater in older adults and those with renal impairment. The risk is lower with metformin and linagliptin than with insulin or sulfonylureas.
How serious is the interaction between Linagliptin-metformin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the course and advise patients on symptoms of dysglycemia; switch antibiotic if glucose disturbances occur.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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