Drug interactions
Linagliptin-metformin + Paroxetine
Severity: Minor
Linagliptin-metformin and Paroxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs such as paroxetine may modestly alter glucose levels and in some patients enhance glucose lowering, with occasional hypoglycemia reported. Paroxetine can also cause weight gain with long-term use. The effect with metformin and linagliptin is usually small.
What this interaction means in plain words
Linagliptin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Linagliptin-metformin belongs to Endocrine; Paroxetine belongs to Central Nervous System.
Why it happens
Serotonergic effects may alter insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor glucose when starting or stopping paroxetine and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Paroxetine?
MediHelp rates the interaction as minor. Linagliptin-metformin and Paroxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. SSRIs such as paroxetine may modestly alter glucose levels and in some patients enhance glucose lowering, with occasional hypoglycemia reported. Paroxetine can also cause weight gain with long-term use. The effect with metformin and linagliptin is usually small.
How serious is the interaction between Linagliptin-metformin and Paroxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping paroxetine and adjust antidiabetic therapy if needed.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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