Drug interactions
Linagliptin-metformin + Phenelzine
Severity: Moderate
Linagliptin-metformin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as phenelzine can lower blood glucose and enhance the effect of antidiabetic agents, with hypoglycemia reported. Risk is greater with insulin or sulfonylureas than with metformin and linagliptin.
What this interaction means in plain words
Linagliptin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibition may enhance insulin sensitivity and secretion; the exact mechanism is not fully established.
What to do
Monitor blood glucose when starting or stopping phenelzine and reduce antidiabetic doses if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Phenelzine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as phenelzine can lower blood glucose and enhance the effect of antidiabetic agents, with hypoglycemia reported. Risk is greater with insulin or sulfonylureas than with metformin and linagliptin.
How serious is the interaction between Linagliptin-metformin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping phenelzine and reduce antidiabetic doses if hypoglycemia occurs.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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