Drug interactions
Linagliptin-metformin + Prednisolone
Severity: Moderate
Linagliptin-metformin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids raise blood glucose and can considerably worsen diabetes control. The effect depends on dose and duration.
What this interaction means in plain words
Linagliptin-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase insulin resistance and hepatic gluconeogenesis, opposing antidiabetic drugs.
What to do
Monitor blood glucose closely during steroid therapy and adjust antidiabetic treatment, reducing it again as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Prednisolone?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids raise blood glucose and can considerably worsen diabetes control. The effect depends on dose and duration.
How serious is the interaction between Linagliptin-metformin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during steroid therapy and adjust antidiabetic treatment, reducing it again as the steroid is tapered.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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