Drug interactions
Linagliptin-metformin + Primidone
Severity: Moderate
Linagliptin-metformin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which induces CYP3A4 and P-gp and is expected to lower linagliptin exposure. This may reduce glucose-lowering efficacy.
What this interaction means in plain words
Linagliptin-metformin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Phenobarbital-mediated CYP3A4 and P-gp induction increases linagliptin clearance.
What to do
Monitor glucose and HbA1c and consider an alternative antidiabetic agent if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Linagliptin-metformin with Primidone?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, which induces CYP3A4 and P-gp and is expected to lower linagliptin exposure. This may reduce glucose-lowering efficacy.
How serious is the interaction between Linagliptin-metformin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and consider an alternative antidiabetic agent if control is inadequate.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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