Drug interactions
Linagliptin-metformin + Quinine
Severity: Moderate
Linagliptin-metformin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine is a cationic drug that may compete with metformin for renal tubular secretion, possibly raising metformin levels. Quinine can also cause hypoglycemia, which may add to glucose lowering.
What this interaction means in plain words
Linagliptin-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linagliptin-metformin belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Competition for renal cation transporters (OCT2/MATE); quinine also stimulates insulin secretion.
What to do
Monitor blood glucose and watch for metformin adverse effects, particularly in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linagliptin-metformin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Linagliptin-metformin with Quinine?
MediHelp rates the interaction as moderate. Linagliptin-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine is a cationic drug that may compete with metformin for renal tubular secretion, possibly raising metformin levels. Quinine can also cause hypoglycemia, which may add to glucose lowering.
How serious is the interaction between Linagliptin-metformin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and watch for metformin adverse effects, particularly in patients with reduced renal function.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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